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Home   COVID-19 treatment studies for Metformin  COVID-19 treatment studies for Metformin  C19 studies: Metformin  Metformin   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 15% Improvement Relative Risk ICU admission 2% Hospitalization 3% c19early.com/mf Wander et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Wander, 64,892 patient metformin prophylaxis study: 15% lower mortality [p<0.0001], 2% lower ICU admission [p=0.62], and 3% lower hospitalization [p=0.09] https://c19p.org/wander
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Prior Glucose-Lowering Medication Use and 30-Day Outcomes Among 64,892 Veterans With Diabetes and COVID-19
Wander et al., Diabetes Care, doi:10.2337/dc21-1351
6 Oct 2021    Source   PDF   Share   Tweet
Retrospective 64,892 veterans with diabetes in the USA, showing lower mortality with existing metformin use.
risk of death, 15.0% lower, RR 0.85, p < 0.001, treatment 29,685, control 35,207, odds ratio converted to relative risk, logistic regression, within 30 days of diagnosis, control prevalance approximated with overall prevalence.
risk of ICU admission, 1.9% lower, RR 0.98, p = 0.62, treatment 29,685, control 35,207, odds ratio converted to relative risk, logistic regression, within 30 days of diagnosis, control prevalance approximated with overall prevalence.
risk of hospitalization, 3.2% lower, RR 0.97, p = 0.09, treatment 29,685, control 35,207, odds ratio converted to relative risk, logistic regression, within 30 days of diagnosis, control prevalance approximated with overall prevalence.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wander et al., 10/6/2021, retrospective, database analysis, USA, North America, peer-reviewed, 8 authors.
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