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0 0.5 1 1.5 2+ Mortality -11% Improvement Relative Risk c19early.com/fm Wallace et al. Famotidine for COVID-19 Prophylaxis Favors famotidine Favors control
Wallace, 7,944 patient famotidine prophylaxis study: 11% higher mortality [p=0.33] https://c19p.org/wallacefm
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Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study
Wallace et al., BMJ Open, doi:10.1136/bmjopen-2021-050051
31 Dec 2021    Source   PDF   Share   Tweet
Retrospective 9,532 hospitalized COVID+ veterans in the USA, showing no significant difference in mortality with famotidine use. The study provides results for use before, after, and before+after. Before+after should more accurately represent prophylaxis up to COVID-19 infection (and continued use). Before included use up to 2 years before, and after included use up to 60 days later.
risk of death, 11.0% higher, RR 1.11, p = 0.33, treatment 98 of 423 (23.2%), control 1,436 of 7,521 (19.1%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wallace et al., 12/31/2021, retrospective, database analysis, USA, North America, peer-reviewed, 6 authors.
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