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0 0.5 1 1.5 2+ Mortality 72% Improvement Relative Risk c19early.com/mf Wallace et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Wallace, 8,173 patient metformin prophylaxis study: 72% lower mortality [p<0.0001] https://c19p.org/wallace
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Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study
Wallace et al., BMJ Open, doi:10.1136/bmjopen-2021-050051
31 Dec 2021    Source   PDF   Share   Tweet
Retrospective 9,532 hospitalized COVID+ veterans in the USA, showing lower mortality with metformin use. The study provides results for use before, after, and before+after. Before+after should more accurately represent prophylaxis up to COVID-19 infection (and continued use). Before included use up to 2 years before, and after included use up to 60 days later.
risk of death, 72.0% lower, HR 0.28, p < 0.001, treatment 103 of 1,203 (8.6%), control 1,536 of 6,970 (22.0%), NNT 7.4, adjusted per study, before+after, propensity score weighting, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wallace et al., 12/31/2021, retrospective, database analysis, USA, North America, peer-reviewed, 6 authors.
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