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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 58% Improvement Relative Risk Ventilation 68% ICU admission 39% c19early.com/no Valsecchi et al. Nitric Oxide for COVID-19 LATE Favors nitric oxide Favors control
Valsecchi, 71 patient nitric oxide late treatment study: 68% lower ventilation [p=0.08] and 39% lower ICU admission [p=0.28] https://c19p.org/valsecchi
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High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia
Valsecchi et al., Obstetrics & Gynecology, doi:10.1097/AOG.0000000000004847
7 Jul 2022    Source   PDF   Share   Tweet
Retrospective 71 hospitalized patients in Israel, 20 treated with inhaled nitric oxide, showing
risk of death, 58.2% lower, RR 0.42, p = 1.00, treatment 0 of 20 (0.0%), control 1 of 51 (2.0%), NNT 51, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 68.1% lower, RR 0.32, p = 0.08, treatment 2 of 20 (10.0%), control 16 of 51 (31.4%), NNT 4.7.
risk of ICU admission, 39.3% lower, RR 0.61, p = 0.28, treatment 5 of 20 (25.0%), control 21 of 51 (41.2%), NNT 6.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Valsecchi et al., 7/7/2022, retrospective, Israel, peer-reviewed, 20 authors, study period March 2020 - December 2021.
Contact: lberra@mgh.harvard.edu.
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Late treatment
is less effective
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