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Home   COVID-19 treatment studies for Vitamin A  COVID-19 treatment studies for Vitamin A  C19 studies: Vitamin A  Vitamin A   Select treatmentSelect treatmentTreatmentsTreatments
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Vitamin A COVID-19 studies. Recent:
Voelkle
Pandya.
Submit updates/corrections.
May 24
Early, Late, PrEP, PEP Covid Analysis (Preprint) (meta analysis)
meta-analysis
Vitamin A for COVID-19: real-time meta analysis of 11 studies
Details   • Statistically significant improvements are seen for recovery, cases, and viral clearance. 4 studies from 3 independent teams in 3 different countries show statistically significant improvements in isolation (2 for the most serious outco..
Apr 30
Levels Voelkle et al., Nutrients, doi:10.3390/nu14091862
death/ICU, ↓76.2%, p=0.004
Prevalence of Micronutrient Deficiencies in Patients Hospitalized with COVID-19: An Observational Cohort Study
Details   Prospective study of 57 consecutive hospitalized COVID-19 patients in Switzerland, showing higher risk of mortality/ICU admission with vitamin A, vitamin D, and zinc deficiency, with statistical significance only for vitamin A and zinc. A..
Apr 20
In Silico Pandya et al., Informatics in Medicine Unlocked, doi:10.1016/j.imu.2022.100951
In Silico
Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach
Details   In Silico study showing significant interaction with SARS-CoV-2 targets for multiple vitamins.
Mar 10
Review DiGuilio et al., International Journal of Molecular Sciences, doi:10.3390/ijms23062995 (Review)
review
Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy
Details   Review of epithelial and endothelial barrier compromise and associated disease risk including COVID-19, and the potential benefits of vitamin A, vitamin D, and zinc for improving barrier function.
Mar 8
Late Elkazzaz et al., medRxiv, doi:10.1101/2022.03.05.22271959 (Preprint)
death, ↓85.7%, p=0.23
13 cis retinoic acid improved the outcomes of COVID-19 patients. A randomized clinical trial
Details   RCT with 20 13-cis-retinoic acid patients and 20 control patients, showing faster recovery and viral clearance with treatment. Aerosolized 13-cis-retinoic acid with increasing dose from 0.2 mg/kg/day to 4 mg/kg/day for 14 days, plus oral..
Feb 28
PrEPPEP Nimer et al., Bosnian Journal of Basic Medical Sciences, doi:10.17305/bjbms.2021.7009
hosp., ↓21.2%, p=0.40
The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization
Details   Retrospective survey based analysis of 2,148 COVID-19 recovered patients in Jordan, showing no significant differences in the risk of severity and hospitalization with vitamin A prophylaxis.
Nov 14
2021
Late Beigmohammadi et al., Trials, doi:10.1186/s13063-021-05795-4
death, ↓88.9%, p=0.11
The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial
Details   Small RCT 60 ICU patients in Iran, 30 treated with vitamins A, B, C, D, and E, showing significant improvement in SOFA score and several inflammatory markers at day 7 with treatment. 5,000 IU vitamin A daily, 600,000 IU vitamin D once, 30..
Aug 23
2021
In Vitro Morita et al., Viruses, doi:10.3390/v13081669 (In Vitro)
In Vitro
All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
Details   In Vitro and In Silico study showing that all-trans retinoic acid is a potent SARS-CoV-2 3CLpro inhibitor, inhibits SARS-CoV-2 replication in VeroE6/TMPRSS2 cells, and is effective against alpha, beta, gamma, and delta variants in Calu-3 ..
Jun 24
2021
Levels Tepasse et al., Nutrients, doi:10.3390/nu13072173
death, ↓69.7%, p=0.04
Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis
Details   Prospective analysis of 40 hospitalized patients and 47 age-matched convalescent patients, showing significantly lower vitamin A levels in critical patients, and significantly lower vitamin A levels in hospitalized patients vs. controls. ..
Mar 30
2021
PrEPPEP Holt et al., Thorax, doi:10.1136/thoraxjnl-2021-217487
cases, ↓56.3%, p=0.41
Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)
Details   Prospective survey-based study with 15,227 people in the UK, showing lower risk of COVID-19 cases with vitamin A, vitamin D, zinc, selenium, probiotics, and inhaled corticosteroids; and higher risk with metformin and vitamin C. Statistica..
Feb 1
2021
Levels Muhammad et al., SAGE Open Medicine, doi:10.1177/2050312121991246 Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria
Details   Case control study with 50 symptomatic COVID-19 patients and 21 healthy controls in Nigeria, showing that COVID-19 patients had significantly lower levels of selenium and zinc, and vitamins A, C, and E. Control patients were younger than ..
Feb 1
2021
Late Sarohan et al., medRxiv, doi:10.1101/2021.01.30.21250844 (Preprint)
death, ↑282.5%, p=0.001
Retinol Depletion in Severe COVID-19
Details   Retrospective 27 severe COVID-19 patients and 23 non-COVID-19 patients, showing signifcantly lower vitamin A levels in COVID-19 patients (0.37mg/L vs. 0.52 mg/L, p<0.001). 10 of 27 COVID-19 patients received vitamin A, with higher mortali..
Jan 31
2021
Early Al-Sumiadai, Systematic Reviews in Pharmacy, 12:1 (Preprint)
progression, ↓66.7%, p=0.27
Therapeutic effect of vitamin A on COVID-19 patients and its prophylactic effect on contacts
Details   Treatment and prophylaxis studies of vitamin A in Iraq. The treatment study contained 100 patients, 50 treated with 200,000IU vitamin A for two days, showing lower progression to severe disease, and shorter duration of symptoms. The proph..
Jan 20
2021
Review Stephensen et al., British Journal of Nutrition, doi:10.1017/S0007114521000246 (Review)
review
Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2
Details   Review of the potential benefits of vitamin A for COVID-19, including maintaining innate and adaptive immunity, minimizing inflammation, supporting repair of respiratory epithelium and preventing fibrosis, and counteracting adverse effect..
Dec 31
2020
Early Al-Sumiadai et al., EurAsian Journal of Biosciences, 14:7347-7350
death, ↓85.7%, p=0.002
Therapeutic effect of Vitamin A on severe COVID-19 patients
Details   Retrospective 70 severe condition patients treated with vitamin A (200,000IU for two days), salbutamol, and budesonide, and 70 patients not treated with vitamin A, showing significantly lower mortality with the addition of vitamin A.
Dec 31
2020
Review Midha et al., Reviews in Medical Virology, doi:10.1002/rmv.2204 (Review)
review
Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings
Details   Review of the potential benefits of vitamin A for COVID-19, including the effect of vitamin A on ACE2 expression in the respiratory tract, potentially improving the generation of protective immune responses to vaccines, and dosage and saf..
Oct 26
2020
Levels Tomasa-Irriguible et al., Metabolites, doi:10.3390/metabo11090565 (preprint 10/26/2020)
ventilation, ↓71.4%, p=0.001
Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave
Details   Retrospective 120 hospitalized patients in Spain showing vitamin A deficiency associated with higher ICU admission.
Aug 15
2020
In Silico Li et al., Aging, doi:10.18632/aging.103888
In Silico
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19
Details   Bioinformatics and network pharmacology analysis identifying potential mechanisms of action of vitamin A for COVID-19.
Jun 24
2020
Review Andrade et al., SciELO preprints, doi:10.1590/SciELOPreprints.839 (Review)
review
Vitamin A and D deficiencies in the prognosis of respiratory tract infections: A systematic review with perspectives for COVID-19 and a critical analysis on supplementation
Details   Systematic review showing deficiencies of vitamins A and D negatively affecting the prognosis of respiratory tract infections.
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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