Retrospective 120 hospitalized patients in Spain showing vitamin A deficiency associated with higher ICU admission.
Tomasa-Irriguible et al., 10/26/2020, retrospective, Spain, Europe, peer-reviewed, 7 authors.
risk of mechanical ventilation, 71.4% lower, RR 0.29, p = 0.001, treatment 4 of 34 (11.8%), control 48 of 86 (55.8%), adjusted per study, odds ratio converted to relative risk, ≥0.3 mg/L, multivariate logistic regression.
risk of ICU admission, 61.3% lower, RR 0.39, p = 0.004, treatment 6 of 34 (17.6%), control 54 of 86 (62.8%), adjusted per study, odds ratio converted to relative risk, ≥0.3 mg/L, multivariate logistic regression.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.