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0 0.5 1 1.5 2+ Mortality -204% Improvement Relative Risk Hospitalization 31% Recovery time 18% primary c19vitaminc.com Thomas et al. NCT04342728 Vitamin C RCT EARLY TREATMENT Favors vitamin C Favors control
Thomas, 98 patient vitamin C early treatment RCT: 18% faster recovery [p=0.15] https://c19p.org/thomasc
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Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial
12 Feb 2021    Source   PDF   Share   Tweet
Small 214 low-risk outpatient RCT showing non-statistically significant faster recovery with zinc and with vitamin C. NCT04342728 (history). A secondary analysis concludes that vitamin C increases recovery rate by 71% (p = 0.036) [pubpeer.com]. See also [patrickholford.com].
risk of death, 204.2% higher, RR 3.04, p = 0.49, treatment 1 of 48 (2.1%), control 0 of 50 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of hospitalization, 30.6% lower, RR 0.69, p = 1.00, treatment 2 of 48 (4.2%), control 3 of 50 (6.0%), NNT 55.
recovery time, 17.9% lower, relative time 0.82, p = 0.15, treatment mean 5.5 (±3.7) n=48, control mean 6.7 (±4.4) n=50, mean time to a 50% reduction in symptoms, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Thomas et al., 12 Feb 2021, Randomized Controlled Trial, USA, peer-reviewed, 11 authors, trial NCT04342728 (history).
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