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0 0.5 1 1.5 2+ Mortality 97% Improvement Relative Risk c19early.com/mf Tamura et al. Metformin for COVID-19 LATE TREATMENT Favors metformin Favors control
Tamura, 188 patient metformin late treatment study: 97% lower mortality [p=0.02] https://c19p.org/tamura
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Outcome and death risk of diabetes patients with Covid-19 receiving pre-hospital and in-hospital metformin therapies
Tamura et al., Diabetology & Metabolic Syndrome, doi:10.1186/s13098-021-00695-8
13 Jul 2021    Source   PDF   Share   Tweet
Retrospective 188 hospitalized patients in Brazil, showing lower risk of mortality with metformin use. Authors note that, although pre-hospital metformin use improved clinical parameters at admission, continuous use during hospitalization is essential. Patients that used pre-hospital metformin therapy but interrupted the treatment during hospitalization showed higher mortality than those that continued metformin therapy.
risk of death, 96.6% lower, OR 0.03, p = 0.02, treatment 115, control 73, adjusted per study, in-hospital use, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tamura et al., 13 Jul 2021, retrospective, Brazil, peer-reviewed, 4 authors, study period 10 March, 2020 - 13 November, 2020.
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Late treatment
is less effective
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