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0 0.5 1 1.5 2+ Mortality 18% Improvement Relative Risk Mechanical ventilation 14% ICU time 20% Hospitalization time 33% Recovery 15% c19early.com/taher.html Favors N-acetylcysteine Favors control
10 June 2021 - Late treatment study
A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome
Taher et al., Pharmacological Reports, doi:10.1007/s43440-021-00296-2 (Peer Reviewed)
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RCT 92 hospitalized patients, 47 treated with NAC, showing non-significant improvements in outcomes. IRCT20120215009014N355. NAC 40mg/kg/day intravenous for 3 days.
risk of death, 17.9% lower, RR 0.82, p = 0.65, treatment 12 of 47 (25.5%), control 14 of 45 (31.1%), NNT 18.
risk of mechanical ventilation, 13.8% lower, RR 0.86, p = 0.67, treatment 18 of 47 (38.3%), control 20 of 45 (44.4%), NNT 16.
ICU time, 20.0% lower, relative time 0.80, p = 0.48, treatment 47, control 45.
hospitalization time, 33.3% lower, relative time 0.67, p = 0.31, treatment 47, control 45.
risk of no recovery, 14.5% lower, RR 0.85, p = 0.41, treatment 25 of 47 (53.2%), control 28 of 45 (62.2%), NNT 11.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Taher et al., 6/10/2021, Double Blind Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 6 authors, average treatment delay 7.0 days.
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