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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 86% Improvement Relative Risk ICU admission 25% Hospitalization 54% c19early.com/sullivan.html Favors conv. plasma Favors control
21 December 2021 - Late treatment study
Randomized Controlled Trial of Early Outpatient COVID-19 Treatment with High-Titer Convalescent Plasma
Sullivan et al., medRxiv, doi:10.1101/2021.12.10.21267485 (Preprint)
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RCT 1,181 outpatients in the USA, mean 6 days from symptom onset, showing lower hospitalization with treatment. NCT04373460.
risk of death, 85.7% lower, RR 0.14, p = 0.12, treatment 0 of 592 (0.0%), control 3 of 589 (0.5%), NNT 196, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 25.4% lower, RR 0.75, p = 0.73, treatment 3 of 592 (0.5%), control 4 of 589 (0.7%), NNT 580.
risk of hospitalization, 54.3% lower, RR 0.46, p = 0.005, treatment 17 of 592 (2.9%), control 37 of 589 (6.3%), NNT 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Sullivan et al., 12/21/2021, Double Blind Randomized Controlled Trial, USA, North America, preprint, 58 authors, study period 3 June, 2020 - 1 October, 2021.
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