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0 0.5 1 1.5 2+ Case 93% Improvement Relative Risk c19hcq.com Simova et al. HCQ for COVID-19 PEP Favors HCQ Favors control
Simova, 204 patient HCQ prophylaxis study: 93% fewer cases [p=0.01] https://c19p.org/simovapep
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Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health care workers
Simova et al., New Microbes and New Infections, doi:10.1016/j.nmni.2020.100813
12 Nov 2020    Source   PDF   Share   Tweet
100% reduction in cases with HCQ+zinc post-exposure prophylaxis. Brief report for healthcare workers in Bulgaria.
0 cases with treatment vs. 3 for control.
156 treatment patients and 48 control patients.
No serious adverse events. This paper reports on both PEP and early treatment, we have separated the two studies.
risk of case, 92.7% lower, RR 0.07, p = 0.01, treatment 0 of 156 (0.0%), control 3 of 48 (6.2%), NNT 16, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Simova et al., 11/12/2020, retrospective, Bulgaria, Europe, peer-reviewed, 5 authors.
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