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Home   COVID-19 treatment studies for Convalescent Plasma  COVID-19 treatment studies for Conv. Plasma  C19 studies: Conv. Plasma  Conv. Plasma   Select treatmentSelect treatmentTreatmentsTreatments
Antiandrogens (meta) Metformin (meta)
Aspirin (meta) Molnupiravir (meta)
Bamlanivimab (meta) N-acetylcys.. (meta)
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 4% Improvement Relative Risk 7-point scale 19% c19early.com/simonovich.html Favors conv. plasma Favors control
24 November 2020 - Late treatment study
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
Simonovich et al., NEJM, doi:0.1056/NEJMoa2031304 (Peer Reviewed)
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RCT 333 hospitalized patients in Argentina, 228 treated with convalescent plasma, showing no significant differences in clinical status or mortality. NCT04383535.
risk of death, 4.1% lower, RR 0.96, p = 1.00, treatment 25 of 228 (11.0%), control 12 of 105 (11.4%), NNT 216.
risk of 7-point scale, 19.0% lower, RR 0.81, p = 0.40, treatment 228, control 105, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Simonovich et al., 11/24/2020, Randomized Controlled Trial, Argentina, South America, peer-reviewed, 39 authors.
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