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Home   COVID-19 treatment studies for Convalescent Plasma  COVID-19 treatment studies for Conv. Plasma  C19 studies: Conv. Plasma  Conv. Plasma   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 4% Improvement Relative Risk 7-point scale 19% c19early.com/cp Simonovich et al. NCT04383535 Conv. Plasma RCT LATE Favors conv. plasma Favors control
Simonovich, 333 patient convalescent plasma late treatment RCT: 4% lower mortality [p=1] and 19% improved 7-point scale results [p=0.4] https://c19p.org/simonovich
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A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
Simonovich et al., NEJM, doi:0.1056/NEJMoa2031304
24 Nov 2020    Source   PDF   Share   Tweet
RCT 333 hospitalized patients in Argentina, 228 treated with convalescent plasma, showing no significant differences in clinical status or mortality. NCT04383535.
risk of death, 4.1% lower, RR 0.96, p = 1.00, treatment 25 of 228 (11.0%), control 12 of 105 (11.4%), NNT 216.
risk of 7-point scale, 19.0% lower, OR 0.81, p = 0.40, treatment 228, control 105, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Simonovich et al., 11/24/2020, Randomized Controlled Trial, Argentina, South America, peer-reviewed, 39 authors, average treatment delay 8.0 days, trial NCT04383535.
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