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Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: signifying strong drug‐drug interactions
Shen et al., Fundamentals of Clinical Pharmacology, doi:10.1111/fcp.12643
28 Dec 2020    Source   PDF   Share   Tweet
Analysis finding that remdesivir at nanomolar concentrations inhibits carboxylesterase‐2 (CES2) through covalent modifications. CES2 is a major drug‐metabolizing enzyme. Authors conclude that caution must be exercised when remdesivir is used along with drugs hydrolyzed by CES2.
Shen et al., 28 Dec 2020, peer-reviewed, 3 authors.
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