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0 0.5 1 1.5 2+ Mortality 20% Improvement Relative Risk Severe case 2% c19early.com/aa Schmidt et al. Antiandrogens for COVID-19 Prophylaxis Favors antiandrogen Favors control
Schmidt, 477 patient various antiandrogen prophylaxis PSM study: 20% lower mortality [p=0.41] and 2% lower severe cases [p=0.94] https://c19p.org/schmidt
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Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19
Schmidt et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.34330
12 Nov 2021    Source   PDF   Share   Tweet
Retrospective 1,106 prostate cancer patients, showing no significant differences in COVID-19 outcomes with ADT.
risk of death, 20.4% lower, RR 0.80, p = 0.41, treatment 25 of 169 (14.8%), control 44 of 308 (14.3%), adjusted per study, odds ratio converted to relative risk, propensity score matching, multivariable.
risk of severe case, 2.0% lower, OR 0.98, p = 0.94, treatment 169, control 308, adjusted per study, propensity score matching, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Schmidt et al., 11/12/2021, retrospective, USA, North America, peer-reviewed, 42 authors, study period 17 March, 2020 - 11 February, 2021.
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