PEP retrospective 625 university students in Thailand offered nitric oxide nasal spray, showing significantly lower cases for students that chose to use the treatment.
Targeted administration to the respiratory tract provides treatment directly
to the typical source of initial SARS-CoV-2 infection and replication, and
allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
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risk of case, 75.0% lower, RR 0.25, p < 0.001, treatment 13 of 203 (6.4%), control 108 of 422 (25.6%), NNT 5.2.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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SaNOtize et al., 30 Apr 2022, retrospective, Thailand, preprint, 1 author.
