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0 0.5 1 1.5 2+ Mortality -100% Improvement Relative Risk Severe case -428% Progression -13% c19early.com/ib Samimagham et al. Ibuprofen for COVID-19 Prophylaxis Favors ibuprofen Favors control
Samimagham, 158 patient ibuprofen prophylaxis study: 100% higher mortality [p=0.001], 428% higher severe cases [p=0.0007], and 13% higher progression [p=0.04] https://c19p.org/samimagham2
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The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality
Samimagham et al., Archives of Clinical Infectious Diseases, doi:10.5812/archcid.106847
13 Jul 2020    Source   PDF   Share   Tweet
Retrospective 158 COVID-19 patients in Iran, showing higher risk of mortality with ibuprofen use.
risk of death, 100% higher, OR 2.00, p < 0.001, treatment 63, control 95, adjusted per study, multivariable, RR approximated with OR.
risk of severe case, 427.8% higher, RR 5.28, p < 0.001, treatment 14 of 63 (22.2%), control 4 of 95 (4.2%).
risk of progression, 13.1% higher, RR 1.13, p = 0.04, treatment 60 of 63 (95.2%), control 80 of 95 (84.2%), moderate or severe.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Samimagham et al., 13 Jul 2020, retrospective, Iran, peer-reviewed, 4 authors.
Contact: mitra.kazemijahromi@gmail.com.
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