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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization time 33% Improvement Relative Risk Recovery 0% Recovery (b) 50% c19early.com/fm Samimagham et al. Famotidine for COVID-19 RCT LATE Favors famotidine Favors control
Samimagham, 20 patient famotidine late treatment RCT: 33% shorter hospitalization [p=0.04] and no change in recovery [p=1] https://c19p.org/samimagham
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The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A phase III randomised clinical trial
Samimagham et al., Research Square, doi:10.21203/rs.3.rs-462937/v1 (Preprint)
27 Apr 2021    Source   PDF   Share   Tweet
Very small RCT with 20 patients in Iran, showing shorter hospitalization time with famotidine treatment. There was no mortality or ICU admission. Famotidine 160mg four times a day. IRCT20200509047364N2.
hospitalization time, 33.3% lower, relative time 0.67, p = 0.04, treatment 10, control 10.
risk of no recovery, no change, RR 1.00, p = 1.00, treatment 5 of 10 (50.0%), control 5 of 10 (50.0%), >50% CT lung involvment.
risk of no recovery, 50.0% lower, RR 0.50, p = 0.37, treatment 3 of 10 (30.0%), control 6 of 10 (60.0%), NNT 3.3, no improvement in cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Samimagham et al., 4/27/2021, Single Blind Randomized Controlled Trial, placebo-controlled, Iran, Middle East, preprint, 6 authors.
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Late treatment
is less effective
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