Association Between Accelerometer-Assessed Physical Activity and Severity of COVID-19 in UK Biobank
PhD Alex V Rowlands, PhD Paddy C Dempsey, PhD Clare Gillies, MPhil David E Kloecker, PhD Cameron Razieh, PhD Yogini Chudasama, PhD Nazrul Islam, PhD Francesco Zaccardi, PhD Claire Lawson, PhD Tom Norris, MD Melanie J Davies, PhD Kamlesh Khunti, PhD Tom Yates
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, doi:10.1016/j.mayocpiqo.2021.08.011
Objective: To quantify the association between accelerometer-assessed physical activity and coronavirus disease 2019 (COVID-19) outcomes.
Research and InnovationeDepartment of Health and Social Care COVID-19 Rapid Response Rolling Call (MR/ V020536/1) and Health Data Research UK (HDRUK2020.138). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Potential Competing Interests: K.K. is a member of the UK Scientific Advisory Group for Emergencies (SAGE), Chair of the SAGE subgroup on ethnicity and COVID-19, and member of Independent SAGE. All other authors declare that they have no competing interests.
References
Anderson, Heesterbeek, Klinkenberg, Hollingsworth, How will country-based mitigation . How will country-based mitigation measures influence the course of the COVID-19 epidemic?, Lancet
Armstrong, Rudkin, Allen, Dynamic linkage of COVID-19 test results between Public Health England's Second Generation Surveillance System and UK Biobank, Microb Genom
Arvidsson, Fridolfsson, Börjesson, Measurement of physical activity in clinical practice using accelerometers, J Intern Med
Batty, Gale, Kivimäki, Deary, Bell, Comparison of risk factor associations in UK Biobank against representative, general population-based studies with conventional response rates: prospective cohort study and individual participant meta-analysis, BMJ
Brawner, Ehman, Bole, Inverse relationship of maximal exercise capacity to hospitalization secondary to coronavirus disease 2019, Mayo Clin Proc
Bull, Al-Ansari, Biddle, World Health Organization 2020 guidelines on physical activity and sedentary behaviour, Br J Sports Med
Chastin, Abaraogu, Bourgois, Effects of regular physical activity on the immune system, vaccination and risk of community-acquired infectious disease in the general population: systematic review and meta-analysis, Sports Med
Doherty, Jackson, Hammerla, Large scale population assessment of physical activity using wrist worn accelerometers: the UK Biobank Study, PLoS One
Gao, Piernas, Astbury, Associations between body-mass index and COVID-19 severity in 6.9 million people in England: a prospective, community-based, cohort study. Lan, cet Diabetes Endocrinol
Griffith, Morrus, Tudball, Collider bias undermines our understanding of COVID-19 disease risk and severity, Nat Comm
Hildebrand, Van Hees, Hansen, Ekelund, Age group comparability of raw accelerometer output from wrist-and hipworn monitors, Med Sci Sports Exerc
Lavie, Sanchis-Gomar, Arena, Fit is it in COVID-19, future pandemics, and overall healthy living, Mayo Clin Proc
Mathur, Rentsch, Morton, Ethnic differences in SARS-CoV-2 infection and COVID-19erelated hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform, Lancet
Migueles, Rowlands, Huber, Sabia, Van Hees et al., GGIR: a research community-driven open-source R-package for generating physical activity and sleep outcomes from multi-day raw accelerometer data, J Measure Phys Behav
Mutambudzi, Niedwiedz, Macdonald, Occupation and risk of severe COVID-19: prospective cohort study of 120, 075 UK Biobank participants, Occup Environ Med
Razieh, Zaccardi, Islam, Ethnic minorities and COVID-19: examining whether excess risk is mediated through deprivation, Eur J Public Health
Rowlands, Edwardson, Davies, Khunti, Harrington et al., Beyond cut points: accelerometer metrics that capture the physical activity profile, Med Sci Sports Exerc
Rowlands, Edwardson, Dawkins, Maylor, Metcalf et al., Physical activity for bone health: how much and/or how hard?, Med Sci Sports Exerc
Rowlands, Gillies, Chudasama, Association of working shifts, inside and outside of healthcare, with severe COVID-19: an observational study, BMC Public Health
Rowlands, Kloecker, Chudasama, Association of balance and timing of physical activity and rest with risk of COVID-19 in UK Biobank, Mayo Clin Proc
Rowlands, Yates, Edwardson, Activity intensity, volume and norms: utility and interpretation of accelerometer metrics, Med Sci Sports Exerc
Sallis, Adlakha, Oyeyemi, An international physical activity and public health research agenda to inform coronavirus disease-2019 policies and practices, J Sport Health Sci
Sallis, Young, Tartof, Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients, Br J Sports Med
Smith, Gardner, Fisher, Hamer, Patterns and correlates of physical activity behaviour over 10 years in older adults: prospective analyses from the English Longitudinal Study of Ageing, BMJ Open
Strain, Wijendaele, Dempsey, Wearable-devicemeasured physical activity and future health risk, Nat Med
Sudlow, Gallacher, Allen, UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age, PLoS Med
Vepa, Bae, Ahmed, Pareek, Khunti, COVID-19 and ethnicity: a novel pathophysiological role for inflammation, Diabetes Metab Syndr
Warburton, Nicol, Bredin, Health benefits of physical activity: the evidence, CMAJ
Yang, Zheng, Gou, Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis, Int J Infect Dis
Yates, Razieh, Zaccardi, Davies, Khunti, Obesity and risk of COVID-19: analysis of UK Biobank, Prim Care Diabetes
Yates, Razieh, Zaccardi, Obesity, walking pace and risk of severe COVID-19: analysis of UK Biobank, Int J Obes (Lond)