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0 0.5 1 1.5 2+ Recovery 31% Improvement Relative Risk c19vitaminc.com Ried et al. Vitamin C for COVID-19 RCT EARLY TREATMENT Favors vitamin C Favors control
Ried, 237 patient vitamin C early treatment RCT: 31% improved recovery [p=0.008] https://c19p.org/ried
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Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial
Ried et al., Cureus, doi:10.7759/cureus.19902
25 Nov 2021    Source   PDF   Share   Tweet
RCT 237 patients in Turkey, 162 treated with IV vitamin C in addition to HCQ/AZ/zinc/vitamin D used for all patients, showing significantly faster recovery with the addition of IV vitamin C.
97% of patients were vitamin D deficient, and lower vitamin D levels were associated with ICU admission and longer hospital stay.
Only 1 of 237 hospitalized patients died (average age 63, range 22-99) - a 70-year-old patient with heart and lung disease and severely deficient vitamin D levels (6 nmol/L). IV vitamin C (sodium ascorbate) was given as 50 mg/kg every six hours on day 1, followed by 100 mg/kg every six hours (four times daily, 400 mg/kg/day) for seven days. ACTRN12620000557932.
risk of no recovery, 30.6% lower, RR 0.69, p = 0.008, treatment 69 of 162 (42.6%), control 46 of 75 (61.3%), NNT 5.3, day 15 mid-recovery.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ried et al., 25 Nov 2021, Randomized Controlled Trial, Turkey, peer-reviewed, 3 authors, average treatment delay 4.0 days.
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