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@CovidAnalysis
All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 9% Improvement Relative Risk Severe case -303% Ibuprofen for COVID-19  Reese et al.  Prophylaxis Is prophylaxis with ibuprofen beneficial for COVID-19? PSM retrospective 11,474 patients in the USA Higher severe cases with ibuprofen (p<0.000001) c19early.org Reese et al., medRxiv, April 2021 Favors ibuprofen Favors control

Cyclooxygenase inhibitor use is associated with increased COVID-19 severity

Reese et al., medRxiv, doi:10.1101/2021.04.13.21255438
Apr 2021  
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N3C retrospective 250,533 patients showing higher COVID-19 severity with ibuprofen use. Note that results for individual treatments are not included in the journal version or v2 of this preprint.
Important missing comments or errors? Let us know.
Study covers ibuprofen, aspirin, and acetaminophen.
risk of death, 9.0% lower, HR 0.91, p = 0.65, treatment 5,737, control 5,737, propensity score matching, Cox proportional hazards, Table S56.
risk of severe case, 303.0% higher, OR 4.03, p < 0.001, treatment 5,737, control 5,737, propensity score matching, Table S48, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Reese et al., 20 Apr 2021, retrospective, USA, preprint, 23 authors.
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