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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 0% primary Improvement Relative Risk Hospital discharge -1% c19early.com/recoverycp.html Favors conv. plasma Favors control
15 January 2021 - Late treatment study
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Recovery Collaborative Group, The Lancet, doi:10.1016/S0140-6736(21)00897-7 (press release 1/15/2021) (Peer Reviewed)
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RCT 16,287 hospitalized patients in the UK, showing no significant differences with convalescent plasma treatment. Subgroup analysis shows better results for those treated <= 7 days from symptom onset. NCT04381936.
risk of death, no change, RR 1.00, p = 0.95, treatment 1,399 of 5,795 (24.1%), control 1,408 of 5,763 (24.4%), NNT 345, day 28.
risk of no hospital discharge, 1.0% higher, RR 1.01, p = 0.57, treatment 1,963 of 5,795 (33.9%), control 1,941 of 5,763 (33.7%), day 28.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Recovery Collaborative Group et al., 1/15/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 1 author.
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