Small RCT 80 hospitalized patients in India, 40 treated with convalescent plasma, not showing significant differences in primary analysis. Authors note that significant improvement in hypoxia, reduction in hospital stay, and survival benefit was seen in severe COVID-19 patients with ARDS aged <67. CTRI/2020/05/025209.
Ray et al., 11/29/2020, Randomized Controlled Trial, India, South Asia, peer-reviewed, 37 authors.
risk of death, 33.0% lower, RR 0.67, p = 0.34, treatment 10 of 40 (25.0%), control 14 of 40 (35.0%), adjusted per study, Mantel-Haenszel.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.