Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study
Luis M Pérez-Belmonte, José David Torres-Peña, María D López-Carmona, M Mar. Ayala-Gutiérrez, Francisco Fuentes-Jiménez, Lucía Jorge Huerta, Jaime Alonso Muñoz, Manuel Rubio-Rivas, Manel Madrazo, Marcos Guzmán Garcia, Beatriz Vicente Montes, Joaquim Fernández Sola, Javier Ena, Ruth Gonzalez Ferrer, Carmen Mella Pérez, Carlos Jorge Ripper, Jose Javier Napal Lecumberri, Iris El Attar Acedo, Susana Plaza Canteli, Sara Fuente Cosío, Francisco Amorós Martínez, Begoña Cortés Rodríguez, Pablo Pérez-Martínez, José Manuel Ramos-Rincón, Ricardo Gómez-Huelgas
BMC Medicine, doi:10.1186/s12916-020-01832-2
Background: Limited evidence exists on the role of glucose-lowering drugs in patients with COVID-19. Our main objective was to examine the association between in-hospital death and each routine at-home glucose-lowering drug both individually and in combination with metformin in patients with type 2 diabetes mellitus admitted for COVID-19. We also evaluated their association with the composite outcome of the need for ICU admission, invasive and non-invasive mechanical ventilation, or in-hospital death as well as on the development of in-hospital complications and a long-time hospital stay.
Supplementary Information Supplementary information accompanies this paper at https://doi.org/10. 1186/s12916-020-01832-2. Additional file 1: Table S1 . Pre-and post-propensity score matching of baseline sociodemographic and clinical characteristics of patients with type 2 diabetes mellitus admitted for coronavirus disease 2019 treated with metformin versus other glucose-lowering drugs. Additional file 2: Table S2 . Pre-and post-propensity score matching of baseline sociodemographic and clinical characteristics of patients with type 2 diabetes mellitus admitted for coronavirus disease 2019 treated with dipeptidyl peptidase-4 inhibitors versus other glucose-lowering drugs. Additional file 3: Table S3 . Pre-and post-propensity score matching of baseline sociodemographic and clinical characteristics of patients with type 2 diabetes mellitus admitted for coronavirus disease 2019 treated with insulin versus other glucose-lowering drugs. Additional file 4: Table S4 . Pre-and post-propensity score matching of baseline sociodemographic and clinical characteristics of patients with type 2 diabetes mellitus admitted for coronavirus disease 2019 treated with metformin plus dipeptidyl peptidase-4 inhibitors versus other glucose-lowering drugs. Additional file 5: Table S5 . Pre-and post-propensity score matching of baseline sociodemographic and clinical characteristics of patients with type 2 diabetes mellitus admitted for coronavirus disease 2019 treated with metformin plus..
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