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0 0.5 1 1.5 2+ Mortality -10% Improvement Relative Risk c19early.com/mf Pérez-Belmonte et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Pérez-Belmonte, 498 patient metformin prophylaxis PSM study: 10% higher mortality [p=0.48] https://c19p.org/perezbelmonte
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Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study
Pérez-Belmonte et al., BMC Medicine, doi:10.1186/s12916-020-01832-2
16 Nov 2020    Source   PDF   Share   Tweet
Retrospective 2,666 type 2 diabetes COVID-19 patients in Spain, showing higher mortality with existing metformin use (not statistically significant).
risk of death, 10.4% higher, RR 1.10, p = 0.48, treatment 79 of 249 (31.7%), control 79 of 249 (31.7%), odds ratio converted to relative risk, mixed effect logistic regression, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pérez-Belmonte et al., 11/16/2020, retrospective, propensity score matching, Spain, Europe, peer-reviewed, 26 authors.
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