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0 0.5 1 1.5 2+ Viral clearance 58% Improvement Relative Risk c19mp.com Optimus et al. Molnupiravir for COVID-19 RCT EARLY Favors molnupiravir Favors control
Optimus, 355 patient molnupiravir early treatment RCT: 58% improved viral clearance [p<0.0001] https://c19p.org/optimus
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Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India
Optimus Press Release (News)
21 Jul 2021    Source   PDF   Share   Tweet
Interim report on CTRI/2021/06/033992, showing faster viral clearance. Event counts are approximate, the press release only provides percentages.
Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom].
risk of no viral clearance, 58.0% lower, RR 0.42, p < 0.001, treatment 38 of 175 (21.7%), control 93 of 180 (51.7%), NNT 3.3, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Optimus et al., 7/21/2021, Randomized Controlled Trial, India, preprint, 1 author.
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