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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -26% Improvement Relative Risk Case 28% c19early.com/oh.html Favors metformin Favors control
13 February 2021 - Prophylaxis study
Metformin use and risk of COVID-19 among patients with type II diabetes mellitus: an NHIS-COVID-19 database cohort study
Oh et al., Acta Diabetologica, doi:10.1007/s00592-020-01666-7 (Peer Reviewed)
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Retrospective 27,493 type II diabetes patients in the USA, 7,204 on metformin, showing significantly lower COVID-19 cases, but no significant difference in mortality.
risk of death, 26.0% higher, RR 1.26, p = 0.30, treatment 5,946, control 5,946, adjusted per study, multivariable, RR approximated with OR.
risk of case, 28.0% lower, RR 0.72, p < 0.001, treatment 390 of 5,946 (6.6%), control 541 of 5,946 (9.1%), NNT 39, adjusted per study, odds ratio converted to relative risk, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Oh et al., 2/13/2021, retrospective, USA, North America, peer-reviewed, 2 authors.
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