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0 0.5 1 1.5 2+ Mortality -26% Improvement Relative Risk Case 28% c19early.com/mf Oh et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Oh, 11,892 patient metformin prophylaxis study: 26% higher mortality [p=0.3] and 28% fewer cases [p<0.0001] https://c19p.org/oh
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Metformin use and risk of COVID-19 among patients with type II diabetes mellitus: an NHIS-COVID-19 database cohort study
Oh et al., Acta Diabetologica, doi:10.1007/s00592-020-01666-7
13 Feb 2021    Source   PDF   Share   Tweet
Retrospective 27,493 type II diabetes patients in the USA, 7,204 on metformin, showing significantly lower COVID-19 cases, but no significant difference in mortality.
risk of death, 26.0% higher, OR 1.26, p = 0.30, treatment 5,946, control 5,946, adjusted per study, multivariable, RR approximated with OR.
risk of case, 28.0% lower, RR 0.72, p < 0.001, treatment 390 of 5,946 (6.6%), control 541 of 5,946 (9.1%), NNT 39, adjusted per study, odds ratio converted to relative risk, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Oh et al., 2/13/2021, retrospective, USA, North America, peer-reviewed, 2 authors.
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