Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Nitric Oxide  COVID-19 treatment studies for Nitric Oxide  C19 studies: Nitric Oxide  Nitric Oxide   Select treatmentSelect treatmentTreatmentsTreatments
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta
Lactoferrin Meta

Other Treatments Global Adoption
 
Nitric Oxide COVID-19 studies. Recent:
Oza
Abou-Arab
Chandel
Valsecchi
Moni
Tandon.
Nitric Oxide has been officially adopted for early treatment in 2 countries. Submit updates/corrections.
Sep 20
Early, Late, PrEP, PEP Covid Analysis (Preprint) (meta analysis)
meta-analysis
Nitric Oxide for COVID-19: real-time meta analysis of 6 studies
Details   • Statistically significant improvements are seen for cases and viral clearance. 4 studies from 3 independent teams in 3 different countries show statistically significant improvements in isolation (2 for the most serious outcome). • Meta..
Aug 24
Review Oza et al., Nitric Oxide, doi:10.1016/j.niox.2022.08.003 (Review)
review
Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise
Details   Extensive review of the mechanisms of action and potential benefits of nitric oxide and hydrogen sulfide for SARS-CoV-2 and other viral infections.
Jul 7
Late Valsecchi et al., Obstetrics & Gynecology, doi:10.1097/AOG.0000000000004847
death, ↓58.2%, p=1.00
High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia
Details   Retrospective 71 hospitalized patients in Israel, 20 treated with inhaled nitric oxide, showing
Jun 29
Early Tandon et al., The Lancet Regional Health - Southeast Asia, doi:10.1016/j.lansea.2022.100036
no improv., ↓41.9%, p=0.06
SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial
Details   RCT with 153 patients treated with a nitric oxide nasal spray, and 153 placebo patients, showing faster viral clearance with treatment. NO generated by a nasal spray (NONS) self-administered six times daily as two sprays per nostril (0.45..
Apr 30
PrEPPEP SaNOtize (Preprint)
cases, ↓75.0%, p<0.0001
Retrospective clinical study for COVID-19 prevention after exposure
Details   PEP retrospective 625 university students in Thailand offered nitric oxide nasal spray, showing significantly lower cases for students that chose to use the treatment.
May 13
2021
Early Winchester et al., Journal of Infection, doi:10.1016/j.jinf.2021.05.009
no improv., ↓42.0%, p=0.008
Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
Details   RCT with 40 nitric oxide and 40 placebo patients in the UK, showing faster viral clearance and greater improvement with treatment.
Apr 20
2021
Late Moni et al., Infectious Microbes and Diseases, doi:10.1097/IM9.0000000000000079 (preprint 4/20/2021)
death, ↓90.1%, p=0.03
Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance: Results of a Pilot Study
Details   RCT 29 ICU patients in India, showing improved clinical outcomes and faster viral clearance with inhaled nitric oxide treatment. The treatment group was younger (mean 54 vs. 66) and had more patients on NIV at baseline (29% vs. 18%).
Jan 31
2021
Late Chandel et al., Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, doi:10.1177/11795484211047065
death, ↑54.1%, p=0.25
Inhaled Nitric Oxide via High-Flow Nasal Cannula in Patients with Acute Respiratory Failure Related to COVID-19
Details   Retrospective 272 acute respitory failure patients in the USA treated with high-flow nasal cannula, 66 treated with inhaled nitric oxide, showing increased mortality with inhaled nitric oxide. There were significant differences in the usa..
Nov 12
2020
Late Abou-Arab et al., Critical Care, doi:10.1186/s13054-020-03371-x Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study
Details   Retrospective 34 ICU patients in France treated with inhaled nitric oxide, showing 65% had an increase in PaO2/FiO2 of >20% 30 min following administration.
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.
Submit