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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 18% Improvement Relative Risk Ventilation -19% Ongoing hospitalization.. -17% primary Hospitalization time -20% c19early.com/aa Nickols et al. NCT04397718 HITCH Degarelix RCT LATE Favors degarelix Favors control
Nickols, 96 patient degarelix antiandrogen late treatment RCT: 18% lower mortality [p=0.66], 19% higher ventilation [p=0.7], 17% worse results [p=0.7], and 20% longer hospitalization [p=0.94] https://c19p.org/nickols
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Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19
Nickols et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2022.7852, HITCH, NCT04397718 (history)
19 Apr 2022    Source   PDF   Share   Tweet
Early terminated RCT with 62 very late stage (79% on oxygen) degarelix patients and 34 placebo patients, showing no significant differences with treatment.
For discussion of many issues with this study see [twitter.com].
risk of death, 18.3% lower, RR 0.82, p = 0.66, treatment 11 of 62 (17.7%), control 7 of 34 (20.6%), NNT 35, adjusted per study, odds ratio converted to relative risk, multivariable.
risk of mechanical ventilation, 18.8% higher, RR 1.19, p = 0.70, treatment 13 of 62 (21.0%), control 6 of 34 (17.6%).
risk of ongoing hospitalization, mortality, or mechanical ventilation, 16.7% higher, RR 1.17, p = 0.70, treatment 15 of 62 (24.2%), control 7 of 34 (20.6%), adjusted per study, odds ratio converted to relative risk, multivariable, primary outcome.
hospitalization time, 20.0% higher, relative time 1.20, p = 0.94, treatment 62, control 34.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nickols et al., 19 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 34 authors, study period 22 July, 2020 - 8 April, 2021, trial NCT04397718 (history) (HITCH).
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Late treatment
is less effective
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