Nguyen: Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses

All Studies Meta Analysis

▶

All Studies Meta Analysis Recent:

Download Image

Nguyen, 2,424 patient cannabidiol prophylaxis study: 50% fewer cases [p=0.006] https://c19p.org/nguyen

copied to clipboard

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses

Nguyen et al., Science Advances, doi:10.1126/sciadv.abi6110 (date from earlier preprint)

20 Jan 2022 Source PDF Share Tweet

Retrospective 1,212 patients in the USA with a history of seizure-related conditions, showing patients treated with CBD100 had significantly lower incidence of COVID-19 cases compared to a matched control group.

In Vitro study showing CBD inhibits SARS-CoV-2 with Vero E6 and Calu-3 cells. Mouse study showing CBD significantly inhibited viral replication in the lung and nasal turbinate.

Authors note that CBD does not inhibit ACE2 expression or the main viral proteases, inhibition occurs after viral entry. Authors stress several limitations for use at this time, including purity, quality, and the formulation of products, and potential lung damage based on administration method.

Authors recommend clinical trials, but do not mention the existing RCT by Crippa et al.

Important missing comments or errors? Let us know.

risk of case, 49.6% lower, RR 0.50, p = 0.006, treatment 26 of 531 (4.9%), control 48 of 531 (9.0%), NNT 24, odds ratio converted to relative risk, active CBD100 users.

risk of case, 32.9% lower, RR 0.67, p = 0.009, treatment 75 of 1,212 (6.2%), control 108 of 1,212 (8.9%), NNT 37, odds ratio converted to relative risk, all CBD100 users.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Nguyen et al., 20 Jan 2022, retrospective, USA, peer-reviewed, 34 authors.

All Studies Meta Analysis Submit Updates or Corrections

This Paper Cannabidiol All

Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit