Nguyen, 2,424 patient cannabidiol prophylaxis study: 50% fewer cases [p=0.006] https://c19p.org/nguyen
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Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
et al., Science Advances, doi:10.1126/sciadv.abi6110 (preprint 3/10/2021)
Retrospective 1,212 patients in the USA with a history of seizure-related conditions, showing patients treated with CBD100 had significantly lower incidence of COVID-19 cases compared to a matched control group.In Vitro study showing CBD inhibits SARS-CoV-2 with Vero E6 and Calu-3 cells. Mouse study showing CBD significantly inhibited viral replication in the lung and nasal turbinate.Authors note that CBD does not inhibit ACE2 expression or the main viral proteases, inhibition occurs after viral entry. Authors stress several limitations for use at this time, including purity, quality, and the formulation of products, and potential lung damage based on administration method.Authors recommend clinical trials, but do not mention the existing RCT by Crippa et al.
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risk of case, 49.6% lower, RR 0.50, p = 0.006, treatment 26 of 531 (4.9%), control 48 of 531 (9.0%), NNT 24, odds ratio converted to relative risk, active CBD100 users.
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risk of case, 32.9% lower, RR 0.67, p = 0.009, treatment 75 of 1,212 (6.2%), control 108 of 1,212 (8.9%), NNT 37, odds ratio converted to relative risk, all CBD100 users.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Nguyen et al., 1/20/2022, retrospective, USA, North America, peer-reviewed, 34 authors.
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