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0 0.5 1 1.5 2+ Mortality -86% Improvement Relative Risk c19early.com/s Mulhem et al. Remdesivir for COVID-19 LATE TREATMENT Favors remdesivir Favors control
Mulhem, 3,219 patient remdesivir late treatment study: 86% higher mortality [p=0.54] https://c19p.org/mulhems
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3219 hospitalised patients with COVID-19 in Southeast Michigan: a retrospective case cohort study
Mulhem et al., BMJ Open, doi:10.1136/bmjopen-2020-042042
7 Apr 2021    Source   PDF   Share   Tweet
Retrospective database analysis of 3,219 hospitalized patients in the USA. Very different results in the time period analysis (Table S2), and results significantly different to other studies for the same medications (e.g., heparin OR 3.06 [2.44-3.83]) suggest significant confounding by indication and confounding by time.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 85.7% higher, RR 1.86, p = 0.54, treatment 1 of 8 (12.5%), control 515 of 3,211 (16.0%), adjusted per study, odds ratio converted to relative risk, logistic regression.
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This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
Mulhem et al., 7 Apr 2021, retrospective, database analysis, USA, peer-reviewed, 3 authors.
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