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Other Treatments Global Adoption
Outcomes in COVID-19 molnupiravir studies
Outcomes in molnupiravir studies. Potential risks of the mechanism of action include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity. There is substantial positive publication bias. Two trials (CTRI/2021/05/033864 and CTRI/2021/08/0354242) have reported no significant efficacy, however the results have not been published.
0 0.5 1 1.5+ All studies 33% 13 15,517 Improvement, Studies, Patients Relative Risk Mortality 43% 5 13,003 Ventilation 48% 2 11,102 Hospitalization 2% 7 13,445 Recovery 15% 5 906 Viral clearance 38% 6 12,550 RCTs 37% 10 4,415 RCT mortality 50% 3 1,901 Peer-reviewed 39% 5 3,678 Early 43% 9 4,714 Late 16% 4 10,803 Molnupiravir for COVID-19 c19early.com/m Aug 2022 Favorsmolnupiravir Favorscontrol
0 0.5 1 1.5+ ALL STUDIES MORTALITY VENTILATION HOSPITALIZATION RECOVERY VIRAL CLEARANCE RCTS RCT MORTALITY PEER-REVIEWED All Early Late Molnupiravir for COVID-19 C19EARLY.COM/M AUG 2022
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Tau​2 = 0.25, I​2 = 71.9%, p = 0.016 Early treatment 43% 0.57 [0.36-0.90] 81/2,310 206/2,404 43% improvement 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Wong (PSM) 45% 0.55 [0.47-0.63] death 2,116 (n) 8,396 (n) Tau​2 = 0.18, I​2 = 64.9%, p = 0.55 Late treatment 16% 0.84 [0.49-1.45] 11/2,332 1/8,471 16% improvement All studies 33% 0.67 [0.49-0.89] 92/4,642 207/10,875 33% improvement 13 molnupiravir COVID-19 studies c19early.com/m Aug 2022 Tau​2 = 0.13, I​2 = 68.2%, p = 0.0069 Effect extraction pre-specified 1 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 77% 0.23 [0.01-5.69] 0/140 1/62 Improvement, RR [CI] Treatment Control Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] 1/709 9/699 Flisiak 39% 0.61 [0.38-0.97] 20/203 63/387 Tau​2 = 0.32, I​2 = 28.0%, p = 0.079 Early treatment 60% 0.40 [0.14-1.11] 21/1,052 73/1,148 60% improvement Arribas (DB RCT) -282% 3.82 [0.50-29.1] 11/216 1/75 Improvement, RR [CI] Treatment Control Wong (PSM) 45% 0.55 [0.47-0.63] 2,116 (n) 8,396 (n) Tau​2 = 1.34, I​2 = 71.3%, p = 0.92 Late treatment -10% 1.10 [0.18-6.80] 11/2,332 1/8,471 -10% improvement All studies 43% 0.57 [0.38-0.84] 32/3,384 74/9,619 43% improvement 5 molnupiravir COVID-19 mortality results c19early.com/m Aug 2022 Tau​2 = 0.06, I​2 = 36.2%, p = 0.0051 Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Flisiak 5% 0.95 [0.39-2.32] 7/203 14/387 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.92 Early treatment 5% 0.95 [0.39-2.32] 7/203 14/387 5% improvement Wong (PSM) 69% 0.31 [0.16-0.61] 2,116 (n) 8,396 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.00064 Late treatment 69% 0.31 [0.16-0.61] 0/2,116 0/8,396 69% improvement All studies 48% 0.52 [0.17-1.57] 7/2,319 14/8,783 48% improvement 2 molnupiravir COVID-19 mechanical ventilation results c19early.com/m Aug 2022 Tau​2 = 0.47, I​2 = 74.4%, p = 0.25 Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) -33% 1.33 [0.14-12.5] hosp. 3/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Yip (PSW) -17% 1.17 [0.99-1.39] hosp. Flisiak -1% 1.01 [0.71-1.43] hosp. time 203 (n) 387 (n) Khoo (DB RCT) 89% 0.11 [0.01-2.03] hosp. 0/90 4/90 Tau​2 = 0.13, I​2 = 67.4%, p = 0.26 Early treatment 22% 0.78 [0.51-1.20] 17/1,414 41/1,519 22% improvement Wong (PSM) 0% 1.00 [0.95-1.04] hosp. time 2,116 (n) 8,396 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.86 Late treatment 0% 1.00 [0.95-1.04] 0/2,116 0/8,396 0% improvement All studies 2% 0.98 [0.81-1.17] 17/3,530 41/9,915 2% improvement 7 molnupiravir COVID-19 hospitalization results c19early.com/m Aug 2022 Tau​2 = 0.02, I​2 = 69.8%, p = 0.81 Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Tau​2 = 0.25, I​2 = 62.8%, p = 0.028 Early treatment 46% 0.54 [0.31-0.94] 35/2,123 110/2,218 46% improvement Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Improvement, RR [CI] Treatment Control Wong (PSM) 45% 0.55 [0.47-0.63] death 2,116 (n) 8,396 (n) Tau​2 = 1.34, I​2 = 71.3%, p = 0.92 Late treatment -10% 1.10 [0.18-6.80] 11/2,332 1/8,471 -10% improvement All studies 39% 0.61 [0.41-0.90] 46/4,455 111/10,689 39% improvement 9 molnupiravir COVID-19 serious outcomes c19early.com/m Aug 2022 Tau​2 = 0.16, I​2 = 68.7%, p = 0.014 Effect extraction pre-specified(most serious outcome) Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hetero (RCT) 33% 0.67 [0.54-0.82] recov. time 371 (n) 370 (n) Improvement, RR [CI] Treatment Control Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 Tau​2 = 0.13, I​2 = 54.4%, p = 0.53 Early treatment 18% 0.82 [0.44-1.52] 8/383 3/376 18% improvement 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Arribas (DB RCT) 1% 0.99 [0.68-1.45] no recov. 72 (n) 75 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.97 Late treatment 1% 0.99 [0.74-1.34] 0/72 0/75 1% improvement All studies 15% 0.85 [0.66-1.11] 8/455 3/451 15% improvement 5 molnupiravir COVID-19 recovery results c19early.com/m Aug 2022 Tau​2 = 0.03, I​2 = 35.2%, p = 0.24 1 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 49% 0.51 [0.22-1.18] viral+ 10/118 9/54 Improvement, RR [CI] Treatment Control Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Tippabhotla (RCT) 59% 0.41 [0.29-0.57] viral+ 42/610 103/610 Khoo (DB RCT) 23% 0.77 [0.58-1.09] viral+ 90 (n) 90 (n) Tau​2 = 0.09, I​2 = 72.6%, p = 0.00035 Early treatment 49% 0.51 [0.36-0.74] 90/993 205/934 49% improvement Arribas (DB RCT) 12% 0.88 [0.62-1.25] viral+ 26/52 34/60 Improvement, RR [CI] Treatment Control Wong (PSM) 17% 0.83 [0.73-0.93] viral+ 2,115 (n) 8,396 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.0021 Late treatment 17% 0.83 [0.74-0.94] 26/2,167 34/8,456 17% improvement All studies 38% 0.62 [0.46-0.84] 116/3,160 239/9,390 38% improvement 6 molnupiravir COVID-19 viral clearance results c19early.com/m Aug 2022 Tau​2 = 0.10, I​2 = 82.7%, p = 0.0016 Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Tau​2 = 0.11, I​2 = 32.1%, p = 0.0009 Early treatment 54% 0.46 [0.30-0.73] 61/2,107 143/2,017 54% improvement 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Tau​2 = 0.00, I​2 = 0.0%, p = 0.77 Late treatment -8% 1.08 [0.67-1.73] 11/216 1/75 -8% improvement All studies 37% 0.63 [0.40-1.00] 72/2,323 144/2,092 37% improvement 10 molnupiravir COVID-19 Randomized Controlled Trials c19early.com/m Aug 2022 Tau​2 = 0.24, I​2 = 56.0%, p = 0.05 Effect extraction pre-specified 1 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 77% 0.23 [0.01-5.69] 0/140 1/62 Improvement, RR [CI] Treatment Control Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] 1/709 9/699 Tau​2 = 0.00, I​2 = 0.0%, p = 0.024 Early treatment 86% 0.14 [0.02-0.78] 1/849 10/761 86% improvement Arribas (DB RCT) -282% 3.82 [0.50-29.1] 11/216 1/75 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -282% 3.82 [0.50-29.1] 11/216 1/75 -282% improvement All studies 50% 0.50 [0.05-5.45] 12/1,065 11/836 50% improvement 3 molnupiravir COVID-19 RCT mortality results c19early.com/m Aug 2022 Tau​2 = 2.97, I​2 = 67.3%, p = 0.58 Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Improvement, RR [CI] Treatment Control Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Tau​2 = 0.46, I​2 = 62.7%, p = 0.098 Early treatment 52% 0.48 [0.21-1.14] 23/1,702 48/1,685 52% improvement Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -282% 3.82 [0.50-29.1] 11/216 1/75 -282% improvement All studies 39% 0.61 [0.25-1.49] 34/1,918 49/1,760 39% improvement 5 molnupiravir COVID-19 peer reviewed trials c19early.com/m Aug 2022 Tau​2 = 0.61, I​2 = 65.2%, p = 0.28 Effect extraction pre-specified(most serious outcome) Favors molnupiravir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Fischer (RCT) 65% 0.35 [0.01-8.33] death 0/55 1/62 Fischer (RCT) 67% 0.33 [0.01-8.03] death 0/62 1/62 Fischer (RCT) 58% 0.42 [0.02-10.0] death 0/23 1/62 Fischer (RCT) -33% 1.33 [0.14-12.5] hosp. 3/140 1/62 Fischer (RCT) -13% 1.13 [0.07-17.6] hosp. 1/55 1/62 Fischer (RCT) -100% 2.00 [0.19-21.5] hosp. 2/62 1/62 Fischer (RCT) 58% 0.42 [0.02-10.0] hosp. 0/23 1/62 Fischer (RCT) 49% 0.51 [0.22-1.18] viral+ 10/118 9/54 Fischer (RCT) 89% 0.11 [0.01-0.86] viral+ 1/53 9/54 Fischer (RCT) 30% 0.70 [0.25-1.93] viral+ 5/43 9/54 Fischer (RCT) -9% 1.09 [0.37-3.18] viral+ 4/22 9/54 Fischer (RCT) 92% 0.08 [0.01-0.62] viral+ 1/117 6/54 Fischer (RCT) 92% 0.08 [0.00-1.34] viral+ 0/53 6/54 Fischer (RCT) 91% 0.09 [0.00-1.48] viral+ 0/42 6/54 Fischer (RCT) 59% 0.41 [0.05-3.20] viral+ 1/22 6/54 Fischer (RCT) 30% 0.70 [0.37-1.36] viral+ 19/137 12/61 Fischer (RCT) 62% 0.38 [0.13-1.12] viral+ 4/53 12/61 Fischer (RCT) -8% 1.08 [0.54-2.18] viral+ 13/61 12/61 Fischer (RCT) 56% 0.44 [0.11-1.83] viral+ 2/23 12/61 Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Hetero (RCT) 33% 0.67 [0.54-0.82] recov. time 371 (n) 370 (n) Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 Khoo (RCT) -100% 2.00 [0.28-14.2] no recov. 4/12 1/6 Khoo (RCT) -100% 2.00 [0.90-4.43] no recov. 4/4 3/6 Khoo (RCT) 0% 1.00 [0.28-3.54] no recov. 2/4 3/6 Khoo (RCT) 0% 1.00 [0.28-3.54] no recov. 2/4 3/6 Khoo (RCT) -50% 1.50 [0.13-17.7] no recov. 1/4 1/6 Khoo (RCT) -200% 3.00 [0.39-23.1] no recov. 2/4 1/6 Khoo (RCT) -50% 1.50 [0.13-17.7] no recov. 1/4 1/6 Jayk Bernal (RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Jayk Bernal (RCT) 30% 0.70 [0.49-0.99] death/hosp. 48/709 68/699 Jayk Bernal (RCT) 94% 0.06 [0.00-0.97] death/hosp. 0/37 9/47 Jayk Bernal (RCT) 50% 0.50 [0.20-1.26] death/hosp. 6/75 13/82 Jayk Bernal (RCT) 24% 0.76 [0.42-1.38] death/hosp. 18/237 22/221 Jayk Bernal (RCT) 42% 0.58 [0.20-1.68] death/hosp. 5/47 7/38 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Tippabhotla (RCT) 46% 0.54 [0.41-0.71] no improv. 67/610 125/610 Tippabhotla (RCT) 52% 0.48 [0.42-0.54] no improv. 199/610 417/610 Tippabhotla (RCT) 25% 0.75 [0.71-0.79] no improv. 433/610 576/610 Tippabhotla (RCT) 59% 0.41 [0.29-0.57] viral+ 42/610 103/610 Tippabhotla (RCT) 81% 0.19 [0.15-0.24] viral+ 62/610 327/610 Tippabhotla (RCT) 78% 0.22 [0.19-0.27] viral+ 113/610 505/610 Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Yip (PSW) -17% 1.17 [0.99-1.39] hosp. Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 Flisiak 5% 0.95 [0.39-2.32] ventilation 7/203 14/387 Flisiak -1% 1.01 [0.71-1.43] hosp. time 203 (n) 387 (n) Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Khoo (DB RCT) 89% 0.11 [0.01-2.03] hosp. 0/90 4/90 Khoo (DB RCT) 23% 0.77 [0.58-1.09] viral+ 90 (n) 90 (n) 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING​1 Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Arribas (DB RCT) -217% 3.17 [0.34-29.8] death 3/71 1/75 Arribas (DB RCT) -317% 4.17 [0.48-36.4] death 4/72 1/75 Arribas (DB RCT) -311% 4.11 [0.47-35.9] death 4/73 1/75 Arribas (DB RCT) 1% 0.99 [0.68-1.45] no recov. 72 (n) 75 (n) Arribas (DB RCT) 12% 0.88 [0.61-1.28] no recov. 73 (n) 75 (n) Arribas (DB RCT) -1% 1.01 [0.69-1.47] no recov. 73 (n) 75 (n) Arribas (DB RCT) 12% 0.88 [0.62-1.25] viral+ 26/52 34/60 Arribas (DB RCT) -2% 1.02 [0.74-1.41] viral+ 29/50 34/60 Arribas (DB RCT) 21% 0.79 [0.56-1.13] viral+ 27/60 34/60 Arribas (DB RCT) 8% 0.92 [0.41-2.08] viral+ 9/53 10/54 Arribas (DB RCT) -48% 1.48 [0.72-3.03] viral+ 14/51 10/54 Arribas (DB RCT) 21% 0.79 [0.34-1.84] viral+ 8/55 10/54 Wong (PSM) 45% 0.55 [0.47-0.63] death 2,116 (n) 8,396 (n) Wong (PSM) 69% 0.31 [0.16-0.61] ventilation 2,116 (n) 8,396 (n) Wong (PSM) 47% 0.53 [0.46-0.62] death/ICU 2,116 (n) 8,396 (n) Wong (PSM) 0% 1.00 [0.95-1.04] hosp. time 2,116 (n) 8,396 (n) Wong (PSM) 17% 0.83 [0.73-0.93] viral+ 2,115 (n) 8,396 (n) molnupiravir COVID-19 outcomes c19early.com/m Aug 2022 1 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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