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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 80% Improvement Relative Risk Symptomatic case 91% Viral clearance 71% primary c19early.com/b Mikhaylov et al. Bromhexine for COVID-19 RCT Prophylaxis Favors bromhexine Favors control
Mikhaylov, 50 patient bromhexine prophylaxis RCT: 91% fewer symptomatic cases [p=0.05] and 71% improved viral clearance [p=0.14] https://c19p.org/mikhaylov
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Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study
Mikhaylov et al., medRxiv, doi:10.1101/2021.03.03.21252855 (Preprint)
8 Mar 2021    Source   PDF   Share   Tweet
Small prophylaxis RCT with 25 treatment and 25 control health care worker, showing lower PCR+, symptomatic cases, and hospitalization with treatment, although not statistically significant with the small sample size.
Bromhexine may be less effective for omicron due to the entry process moving towards TMPRSS2-independent fusion.
risk of hospitalization, 80.0% lower, RR 0.20, p = 0.49, treatment 0 of 25 (0.0%), control 2 of 25 (8.0%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of symptomatic case, 90.9% lower, RR 0.09, p = 0.05, treatment 0 of 25 (0.0%), control 5 of 25 (20.0%), NNT 5.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no viral clearance, 71.4% lower, RR 0.29, p = 0.14, treatment 2 of 25 (8.0%), control 7 of 25 (28.0%), NNT 5.0, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mikhaylov et al., 8 Mar 2021, Randomized Controlled Trial, Russia, preprint, 8 authors.
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