Conv. Plasma
Nigella Sativa
Vitamin A
Vitamin C
Vitamin D

Home   COVID-19 treatment studies for Metformin  COVID-19 treatment studies for Metformin  C19 studies: Metformin  Metformin   Select treatmentSelect treatmentTreatmentsTreatments
Aspirin Metformin
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Colchicine Probiotics
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Other Adoption (DB RCT)-15%1.15 [0.73-1.83]hosp./ER32/21727/206Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Early treatment-15%1.15 [0.73-1.83]32/21727/206-15% improvementLuo75%0.25 [0.07-0.84]death3/10422/179Improvement, RR [CI]TreatmentControlWang58%0.42 [0.01-1.98]death1/913/49Chen33%0.67 [0.20-1.78]death4/4315/77Bramante7%0.93 [0.81-1.06]death394/2,333791/3,923Crouse61%0.39 [0.16-0.87]death8/7634/144Wander15%0.85 [0.80-0.90]deathTau​2 = 0.01; I​2 = 56.6%PrEP17%0.83 [0.71-0.97]410/2,565875/4,37217% improvementAll studies15%0.85 [0.73-0.99]442/2,782902/4,57815% improvement7 metformin COVID-19 Oct 17, 2021Tau​2 = 0.01; I​2 = 53.7%; Z = 2.13Effect extraction pre-specifiedFavors metforminFavors control
Database of all metformin COVID-19 studies. Studies to date are mostly with diabetic patients. Submit updates/corrections.
Oct 6
PrEP Wander et al., Diabetes Care, doi:10.2337/dc21-1351 (Peer Reviewed) death, ↓15.0%, p<0.0001 Prior Glucose-Lowering Medication Use and 30-Day Outcomes Among 64,892 Veterans With Diabetes and COVID-19
Details   Retrospective 64,892 veterans with diabetes in the USA, showing lower mortality with existing metformin use.
Aug 31
Early Reis et al., Preprint (Preprint) hosp./ER, ↑15.0%, p=0.56 Effect of Early Treatment with Metformin on Risk of Emergency Care and Hospitalization Among Patients with COVID-19: The TOGETHER Randomized Platform Clinical Trial
Details   RCT with 217 patients treated with metformin and 206 controls, showing no significant difference with treatment. Limited information is provided in the preprint. Time since symptom onset is not specified. The trial may share some similar ..
Jan 13
PrEP Crouse et al., Front. Endocrinol., doi:10.3389/fendo.2020.600439 (Peer Reviewed) death, ↓60.8%, p=0.02 Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes
Details   Retrospective 219 COVID-19+ diabetes patients in the USA, showing lower mortality with existing metformin treatment.
Dec 3
PrEP Bramante et al., The Lancet Healthy Longevity, doi:10.1016/S2666-7568(20)30033-7 (Peer Reviewed) death, ↓7.2%, p=0.15 Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis
Details   Retrospective 6,256 COVID-19+ diabetes patients in the USA, showing lower mortality with existing metformin treatment, statistically significant only for women.
Jul 31
PrEP Chen et al., Diabetes Care, doi:10.2337/dc20-0660 (Peer Reviewed) death, ↓33.0%, p=0.46 Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication
Details   Retrospective 120 COVID-19 diabetes patients, showing non-statistically significantly lower mortality with existing metformin treatment.
Jul 14
PrEP Wang et al., Journal of Hematology & Oncology, doi:10.1186/s13045-020-00934-x (Peer Reviewed) death, ↓57.7%, p=0.43 A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward
Details   Retrospective 58 multiple myeloma COVID-19 patients in the USA, showing non-statistically significant lower mortality with metformin treatment.
May 21
PrEP Luo et al., The American Journal of Tropical Medicine and Hygiene, doi:10.4269/ajtmh.20-0375 (Peer Reviewed) death, ↓74.7%, p=0.02 Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis
Details   Retrospective 283 COVID-19+ diabetes patients in China, showing lower mortality with existing metformin treatment.
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
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Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.