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0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk Death/intubation 50% c19early.com/fm Mather et al. Famotidine for COVID-19 Prophylaxis Favors famotidine Favors control
Mather, 772 patient famotidine prophylaxis PSM study: 61% lower mortality [p=0.004] and 50% lower combined mortality/intubation [p=0.003] https://c19p.org/mather
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Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19
Mather et al., American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000832
26 Aug 2020    Source   PDF   Share   Tweet
PSM retrospective 878 hospitalized patients in the USA, 83 with existing famotidine use, showing significantly lower mortality with treatment.
risk of death, 61.4% lower, HR 0.39, p = 0.004, treatment 83, control 689, propensity score matching, Cox proportional hazards.
risk of death/intubation, 50.5% lower, HR 0.49, p = 0.003, treatment 83, control 689, propensity score matching, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mather et al., 8/26/2020, retrospective, USA, North America, peer-reviewed, 3 authors.
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