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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Case 7% Improvement Relative Risk c19early.com/aa MacFadden et al. Spironolactone for COVID-19 Prophylaxis Favors spironolactone Favors control
MacFadden, spironolactone antiandrogen prophylaxis study: 7% fewer cases [p=0.008] https://c19p.org/macfaddenaa
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Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications
MacFadden et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156
29 Mar 2022    Source   PDF   Share   Tweet
Retrospective 26,121 cases and 2,369,020 controls ≥65yo in Canada, showing lower cases with chronic use of spironolactone.
risk of case, 7.0% lower, OR 0.93, p = 0.008, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
MacFadden et al., 3/29/2022, retrospective, Canada, North America, peer-reviewed, 9 authors, study period 15 January, 2020 - 31 December, 2020.
Contact: dmacfadden@toh.ca.
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