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0 0.5 1 1.5 2+ Mortality 50% Improvement Relative Risk Ventilation 50% ICU admission 67% Progression 48% c19early.com/cp Libster et al. NCT04479163 Conv. Plasma RCT EARLY Favors conv. plasma Favors control
Libster, 160 patient convalescent plasma early treatment RCT: 67% lower ICU admission [p=0.17] and 48% lower progression [p=0.03] https://c19p.org/libster
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Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Libster et al., NEJM, doi:10.1056/NEJMoa2033700
6 Jan 2021    Source   PDF   Share   Tweet
RCT 160 patients >=65 with symptom onset <72 hours, 80 treated with convalescent plasma, showing lower progression to severe disease with treatment. NCT04479163.
risk of death, 50.0% lower, RR 0.50, p = 0.43, treatment 2 of 80 (2.5%), control 4 of 80 (5.0%), NNT 40.
risk of mechanical ventilation, 50.0% lower, RR 0.50, p = 0.43, treatment 2 of 80 (2.5%), control 4 of 80 (5.0%), NNT 40.
risk of ICU admission, 67.0% lower, RR 0.33, p = 0.17, treatment 2 of 80 (2.5%), control 6 of 80 (7.5%), NNT 20.
risk of progression, 48.0% lower, RR 0.52, p = 0.03, treatment 13 of 80 (16.2%), control 25 of 80 (31.2%), NNT 6.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Libster et al., 1/6/2021, Double Blind Randomized Controlled Trial, Argentina, South America, peer-reviewed, 56 authors, trial NCT04479163.
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