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Antiandrogen study #4   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Death/ICU -23% Imp. Relative Risk, 95% CI Lazzeri: Impact of anti-androgen therapies on COVID-19 susceptibi.. c19early.com/lazzeri.html Favors antiandrogen Favors control
9/21 Prophylaxis study
Lazzeri et al., medRxiv, doi:10.1101/2020.04.20.20068056 (Preprint)
Impact of anti-androgen therapies on COVID-19 susceptibility: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)
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Retrospective case-control study in Italy with 943 male COVID-19 patients, 45 on chronic 5ARI treatment (finasteride/dutasteride). There was significantly fewer COVID-19 patients >55 on 5ARI treatment compared to age-matched controls (5.57 vs. 8.14%, p=0.0083). The difference was greater for men aged >65 (7.14 vs. 12.31%, p=0.0001). There was no significant difference for ICU admission or death.
risk of death/ICU, 23.0% higher, RR 1.23, p = 0.33, multivariable, RR approximated with OR.
Lazzeri et al., 9/21/2020, retrospective, Italy, Europe, preprint, 11 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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