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0 0.5 1 1.5 2+ Death/ICU -23% Improvement Relative Risk c19early.com/aa Lazzeri et al. Antiandrogens for COVID-19 Prophylaxis Favors antiandrogen Favors control
Lazzeri, various antiandrogen prophylaxis study: 23% higher combined mortality/ICU admission [p=0.33] https://c19p.org/lazzeri
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Impact of anti-androgen therapies on COVID-19 susceptibility: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)
Lazzeri et al., medRxiv, doi:10.1101/2020.04.20.20068056 (Preprint)
21 Sep 2020    Source   PDF   Share   Tweet
Retrospective case-control study in Italy with 943 male COVID-19 patients, 45 on chronic 5ARI treatment (finasteride/dutasteride). There was significantly fewer COVID-19 patients >55 on 5ARI treatment compared to age-matched controls (5.57 vs. 8.14%, p=0.0083). The difference was greater for men aged >65 (7.14 vs. 12.31%, p=0.0001). There was no significant difference for ICU admission or death.
risk of death/ICU, 23.0% higher, OR 1.23, p = 0.33, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lazzeri et al., 9/21/2020, retrospective, Italy, Europe, preprint, 11 authors.
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