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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 52% Improvement Relative Risk c19early.com/lally.html Favors metformin Favors control
31 January 2021 - Prophylaxis study
Metformin is Associated with Decreased 30-Day Mortality Among Nursing Home Residents Infected with SARS-CoV2
Lally et al., Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2020.10.031 (Peer Reviewed)
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Retrospective 775 nursing home residents in the USA, showing lower mortality with existing metformin use.
risk of death, 52.0% lower, RR 0.48, p = 0.009, treatment 16 of 127 (12.6%), control 144 of 648 (22.2%), NNT 10, adjusted per study, multivariable regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Lally et al., 1/31/2021, retrospective, USA, North America, peer-reviewed, 6 authors.
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