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0 0.5 1 1.5 2+ Mortality 60% Improvement Relative Risk Progression 53% c19early.com/aa Kotani et al. Antiandrogens for COVID-19 META Favors antiandrogen Favors control
Kotani, antiandrogen meta analysis: 60% lower mortality [p=0.0004] and 53% lower progression [p=0.003] https://c19p.org/kotani
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Antiandrogen Agents in COVID-19: A Meta-Analysis of Randomized Trials
Kotani et al., SSRN Electronic Journal, doi:10.2139/ssrn.4181700 (Preprint) (meta analysis)
4 Aug 2022    Source   PDF   Share   Tweet
Meta analysis of 12 studies, showing significantly lower mortality with antiandrogen treatment.
Currently there are 45 antiandrogens for COVID-19 studies, showing 40% [21‑54%] lower mortality, 49% [27‑64%] lower ventilation, 32% [1‑53%] lower ICU admission, 30% [9‑47%] lower hospitalization, and 9% [1‑15%] lower cases.
risk of death, 60.0% lower, RR 0.40, p < 0.001.
risk of progression, 53.0% lower, RR 0.47, p = 0.003.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kotani et al., 4 Aug 2022, preprint, 9 authors.
Contact: landoni.giovanni@hsr.it.
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