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0 0.5 1 1.5 2+ Mortality 23% Improvement Relative Risk c19early.com/mf Khunti et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Khunti, 2,851,465 patient metformin prophylaxis study: 23% lower mortality [p<0.0001] https://c19p.org/khunti
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Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England
Khunti et al., The Lacent Diabetes & Endocrinology, doi:10.1016/S2213-8587(21)00050-4
30 Mar 2021    Source   PDF   Share   Tweet
Retrospective 2,851,465 people with type 2 diabetes in the UK, showing lower mortality with existing metformin use. Results are subject to confounding by indication because metformin is typically used early in the progression of type 2 diabetes.
risk of death, 23.0% lower, HR 0.77, p < 0.001, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Khunti et al., 3/30/2021, retrospective, population-based cohort, United Kingdom, Europe, peer-reviewed, 15 authors.
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