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Metformin study #8   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 23% Imp. Relative Risk, 95% CI Khunti: Prescription of glucose-lowering therapies and risk of C.. c19early.com/khunti.html Favors metformin Favors control
3/30 Prophylaxis study
Khunti et al., The Lacent Diabetes & Endocrinology, doi:10.1016/S2213-8587(21)00050-4 (Peer Reviewed)
Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England
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Retrospective 2,851,465 people with type 2 diabetes in the UK, showing lower mortality with existing metformin use. Results are subject to confounding by indication because metformin is typically used early in the progression of type 2 diabetes.
risk of death, 23.0% lower, RR 0.77, p < 0.001, adjusted per study.
Khunti et al., 3/30/2021, retrospective, population-based cohort, United Kingdom, Europe, peer-reviewed, 15 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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