FinnGen Mendelian randomization study showing higher risk of COVID-19 mortality, hospitalization, and infection with insomnia.
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risk of death, 39.0% lower, OR 0.61, p = 0.001, inverted to make OR<1 favor higher quality sleep, RR approximated with OR.
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risk of hospitalization, 32.0% lower, OR 0.68, p < 0.001, inverted to make OR<1 favor higher quality sleep, RR approximated with OR.
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risk of case, 7.4% lower, OR 0.93, p = 0.04, inverted to make OR<1 favor higher quality sleep, RR approximated with OR.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Jones et al., 21 Jul 2022, retrospective, multiple countries, peer-reviewed, 12 authors.
PUBLIC HEALTH IMPACT OF POOR SLEEP ON COVID-19, INFLUENZA AND UPPER RESPIRATORY INFECTIONS
S E Jones, F I Maisha, S Strausz, B Cade, A Tervi, V Helaakoski, M Broberg, V Lammi, J M Lane, S Redline, R Saxena, H M Ollila, L S Castro, L Baraças, G Hashioka, C Bonadio, H Hachul, R Santos-Silva, D Poyares
there were significant differences in the ASRS (t¼-6.175, p<0.001), WURS (t¼-6.087, p<0.01), p<0.001), p<0.001), p<0.01). Psychological characteristics differed significantly in ASRS (F¼22.517, p<0.001, aIn comparison of the insomnia-positive group to the insomnia-negative group, the OR was 4.088 in the PHQ-9 positive group (95% CI: 2.02-8.28) and 2.286 in the MDQ positive group (95% CI: 1.38-2.86). Conclusions: Insomnia was associated with a variety of mental symptoms, and the psychological symptoms were shown to be severe according to the severity of insomnia. Therefore, adequate intervention is needed to improve the symptoms of insomnia.
