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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Progression -8% Case -68% c19early.com/aa Jiménez-Alcaide et al. Antiandrogens for COVID-19 Prophylaxis Favors various Favors control
Jiménez-Alcaide, 1,349 patient various antiandrogen prophylaxis study: 33% lower mortality [p=0.41], 8% higher progression [p=0.77], and 68% more cases [p=0.15] https://c19p.org/jimenezalcaide
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Influence of androgen deprivation therapy on the severity of COVID‐19 in prostate cancer patients
Jiménez-Alcaide et al., The Prostate, doi:10.1002/pros.24232
13 Sep 2021    Source   PDF   Share   Tweet
Retrospective 1,349 prostate cancer patients in Spain, 156 on ADT, showing no significant differences in COVID-19 outcomes with treatment.
risk of death, 33.0% lower, RR 0.67, p = 0.41, treatment 3 of 11 (27.3%), control 17 of 50 (34.0%), adjusted per study, multivariable.
risk of progression, 8.0% higher, RR 1.08, p = 0.77, treatment 11, control 50, adjusted per study, multivariable.
risk of case, 68.2% higher, RR 1.68, p = 0.15, treatment 11 of 156 (7.1%), control 50 of 1,193 (4.2%), excluded in exclusion analyses: excessive unadjusted differences between groups.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jiménez-Alcaide et al., 13 Sep 2021, retrospective, Spain, peer-reviewed, 9 authors.
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