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0 0.5 1 1.5 2+ Case 77% Improvement Relative Risk c19early.com/aa Jeon et al. Antiandrogens for COVID-19 Prophylaxis Favors antiandrogen Favors control
Jeon, 294 patient spironolactone antiandrogen prophylaxis study: 77% fewer cases [p=0.005] https://c19p.org/jeon
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Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea
Jeon et al., Frontiers in Medicine, doi:10.3389/fmed.2021.629176
23 Feb 2021    Source   PDF   Share   Tweet
Retrospective 6,462 liver cirrhosis patients in South Korea, with 67 COVID+ cases, showing significantly lower COVID-19 cases with spironolactone treatment. Death and ICU results per group are not provided. Complications in this study included receipt of antivirals, e.g., treatment with oseltamivir.
risk of case, 77.0% lower, OR 0.23, p = 0.005, treatment 6 of 49 (12.2%) cases, 89 of 245 (36.3%) controls, NNT 6.5, case control OR, model 2, within 3 months.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jeon et al., 2/23/2021, retrospective, South Korea, Asia, peer-reviewed, 3 authors.
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