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0 0.5 1 1.5 2+ Mortality 26% Improvement Relative Risk c19early.com/na Izquierdo et al. N-acetylcys.. for COVID-19 LATE Favors N-acetylcysteine Favors control
Izquierdo, 19,208 patient N-acetylcysteine late treatment study: 26% lower mortality [p=0.0007] https://c19p.org/izquierdo
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Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19
Izquierdo et al., Science Progress, doi:10.1177/00368504221074574
27 Jan 2022    Source   PDF   Share   Tweet
Retrospective 19,208 COVID+ hospitalized patients in Spain, 2,071 treated with high dose NAC, showing lower mortality with treatment. In multivariable analysis, authors adjust for corticosteroids, but do not adjust for HCQ use which was also significantly more common in the NAC group. NAC 600mg every 8 hours.
risk of death, 25.6% lower, RR 0.74, p < 0.001, treatment 136 of 2,071 (6.6%), control 1,935 of 17,137 (11.3%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: significant unadjusted confounding possible.
Izquierdo et al., 1/27/2022, retrospective, Spain, Europe, peer-reviewed, 7 authors, study period 1 March, 2020 - 24 January, 2021.
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