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13 ibuprofen COVID-19 controlled studies, 1 RCTs
-52% improvement
for early treatment, RR
1.52
[0.52-4.51]
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Rinott
-21%
1.21 [0.33-4.38]
death
3/87
9/316
Improvement, RR [CI]
Treatment
Control
Rinott
-12%
1.12 [0.37-3.34]
ventilation
4/87
13/316
Rinott
-40%
1.40 [0.51-3.81]
ICU
5/87
13/316
Abu Esba
-170%
2.70 [0.33-22.0]
death
1/40
11/357
Abu Esba
37%
0.63 [0.07-5.44]
death
40 (n)
357 (n)
Abu Esba
-45%
1.45 [0.44-4.81]
oxygen
40 (n)
357 (n)
Abu Esba
-18%
1.18 [0.59-2.36]
hosp.
40 (n)
357 (n)
Abu Esba
-85%
1.85 [0.42-8.13]
severe case
40 (n)
357 (n)
Sobhy (DB RCT)
52%
0.48 [0.24-0.95]
ICU
10/90
21/90
OT1
Sobhy (DB RCT)
52%
0.48 [0.24-0.95]
oxygen
10/90
21/90
OT1
Sobhy (DB RCT)
26%
0.74 [0.58-0.94]
hosp. time
90 (n)
90 (n)
OT1
Sobhy (DB RCT)
25%
0.75 [0.17-3.26]
no recov.
3/90
4/90
OT1
Sobhy (DB RCT)
43%
0.57 [0.25-1.29]
no recov.
8/90
14/90
OT1
Sobhy (DB RCT)
48%
0.52 [0.28-0.95]
no recov.
13/90
25/90
OT1
Sobhy (DB RCT)
41%
0.59 [0.37-0.94]
no recov.
20/90
34/90
OT1
Choi (PSM)
-240%
3.40 [0.64-18.1]
progression
case control
Samimagham
-100%
2.00 [1.33-3.02]
death
63 (n)
95 (n)
Samimagham
-428%
5.28 [1.82-15.3]
severe case
14/63
4/95
Samimagham
-13%
1.13 [1.02-1.25]
progression
60/63
80/95
Kragholm
4%
0.96 [0.72-1.23]
progression
264 (n)
3,738 (n)
Wong
-23%
1.23 [0.90-1.68]
death
population-based cohort
Wong
17%
0.83 [0.56-1.25]
death
population-based cohort
Reese (PSM)
9%
0.91 [0.62-1.35]
death
5,737 (n)
5,737 (n)
Reese (PSM)
-303%
4.03 [3.69-4.40]
severe case
5,737 (n)
5,737 (n)
Drake
10%
0.90 [0.71-1.13]
death
n/a
n/a
Leal
3%
0.97 [0.94-1.00]
cases
n/a
n/a
Campbell (PSW)
0%
1.00 [0.99-1.01]
death
1,814 (n)
20,311 (n)
Campbell (PSW)
1%
0.99 [0.98-1.00]
death
1,814 (n)
20,311 (n)
Xie
-12%
1.12 [0.92-1.38]
hosp.
population-based cohort
OT1
Xie
-8%
1.08 [0.95-1.22]
cases
population-based cohort
OT1
Loucera
48%
0.52 [0.34-0.78]
death
519 (n)
15,449 (n)
Ibuprofen COVID-19 outcomes
c19 early .org
April 2024
1 OT: comparison with other treatment
Favors ibuprofen
Favors control
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