Hunt, 26,508 patient metformin early treatment study: 67% lower mortality [p<0.0001] https://c19p.org/huntmf
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Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans
et al., Journal of General Internal Medicine, doi:10.1007/s11606-022-07701-3
Retrospective 26,508 consecutive COVID+ veterans in the USA, showing lower mortality with multiple treatments including metformin. Treatment was defined as drugs administered ≥50% of the time within 2 weeks post-COVID+, and may be a continuation of prophylactic treatment in some cases, and may be early or late treatment in other cases. Further reduction in mortality was seen with combinations of treatments.
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risk of death, 67.0% lower, RR 0.33, p < 0.001, treatment 73 of 3,956 (1.8%), control 1,539 of 22,552 (6.8%), NNT 20, adjusted per study, day 30.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Hunt et al., 6/29/2022, retrospective, USA, peer-reviewed, 8 authors, study period 1 March, 2020 - 10 September, 2020.
hunt
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