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Home   COVID-19 treatment studies for Bamlanivimab/etesevimab  COVID-19 treatment studies for Bamlaniv../e..  C19 studies: Bamlaniv../e..  Bamlaniv../e..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Hospitalization/ER 71% Improvement Relative Risk Hospitalization/ER (b) 80% Hospitalization/ER (c) 75% Hospitalization/ER (d) 56% Hospitalization/ER (e) 92% c19ly.com Gottlieb et al. Bamlaniv../e.. for COVID-19 RCT EARLY Favors bamlanivimab/e.. Favors control
Gottlieb, 153 patient bamlanivimab/etesevimab early treatment RCT: 71% fewer combined hospitalization/ER visits [p=0.05] https://c19p.org/gottlieb
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Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19
Gottlieb et al., JAMA, doi:10.1001/jama.2021.0202
21 Jan 2021    Source   PDF   Share   Tweet
RCT for LY-CoV555 monotherapy and LY-CoV555/LY-CoV016 combination therapy with 592 patients showing lower hospitalization/ER visits with treatment.
For viral load at day 11, a statistically significant reduction was found with combination therapy but not monotherapy.
Efficacy is highly variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, VanBlargan].
risk of hospitalization/ER, 70.6% lower, RR 0.29, p = 0.046, treatment 4 of 101 (4.0%), control 7 of 52 (13.5%), NNT 11, LY-CoV555 all dosages.
risk of hospitalization/ER, 79.9% lower, RR 0.20, p = 0.13, treatment 1 of 37 (2.7%), control 7 of 52 (13.5%), NNT 9.3, LY-CoV555 700mg.
risk of hospitalization/ER, 75.2% lower, RR 0.25, p = 0.25, treatment 1 of 30 (3.3%), control 7 of 52 (13.5%), NNT 9.9, LY-CoV555 2800mg.
risk of hospitalization/ER, 56.3% lower, RR 0.44, p = 0.31, treatment 2 of 34 (5.9%), control 7 of 52 (13.5%), NNT 13, LY-CoV555 7000mg.
risk of hospitalization/ER, 91.8% lower, RR 0.08, p = 0.04, treatment 0 of 31 (0.0%), control 7 of 52 (13.5%), NNT 7.4, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), LY-CoV555/LY-CoV016.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gottlieb et al., 21 Jan 2021, Randomized Controlled Trial, USA, peer-reviewed, 27 authors, average treatment delay 4.0 days.
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