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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 4% primary Improvement Relative Risk Time to discharge 12% c19early.com/gharbharan.html Favors conv. plasma Favors control
27 May 2020 - Late treatment study
Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection
Gharbharan et al., Nature Communications, doi:10.1038/s41467-021-23469-2 (Peer Reviewed)
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RCT 86 hospitalized patients, 43 treated with convalescent plasma, not showing significant differences with treatment. Authors conclude that the most likely explanation was already high antibody titers on the day of inclusion, and they recommend treating patients early. NCT04342182.
risk of death, 3.8% lower, RR 0.96, p = 0.95, treatment 6 of 43 (14.0%), control 11 of 43 (25.6%), NNT 8.6, adjusted per study, odds ratio converted to relative risk, multivariable logistic regression.
time to discharge, 11.7% lower, relative time 0.88, p = 0.68, treatment 43, control 43, adjusted per study, multivariable Fine and Gray regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Gharbharan et al., 5/27/2020, Randomized Controlled Trial, Netherlands, Europe, peer-reviewed, 32 authors, average treatment delay 10.0 days.
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