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0 0.5 1 1.5 2+ Mortality 66% Improvement Relative Risk Hospitalization 29% ARDS 68% c19early.com/mf Ghany et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Ghany, 1,139 patient metformin prophylaxis study: 66% lower mortality [p=0.0002], 29% lower hospitalization [p=0.008], and 68% lower ARDS [p<0.0001] https://c19p.org/ghany
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Metformin is associated with lower hospitalizations, mortality and severe coronavirus infection among elderly medicare minority patients in 8 states in USA
Ghany et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.02.022
31 Mar 2021    Source   PDF   Share   Tweet
Retrospective 1,139 elderly COVID+ patients in the USA, 392 with pre-existing metformin use, showing significantly lower mortality, hospitalization, and ARDS with treatment.
risk of death, 66.0% lower, HR 0.34, p < 0.001, treatment 392, control 747, adjusted per study, multivariable, Cox proportional hazards.
risk of hospitalization, 29.0% lower, HR 0.71, p = 0.008, treatment 392, control 747, adjusted per study, multivariable, Cox proportional hazards.
risk of ARDS, 68.0% lower, HR 0.32, p < 0.001, treatment 392, control 747, adjusted per study, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ghany et al., 3/31/2021, retrospective, USA, North America, peer-reviewed, 8 authors.
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