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0 0.5 1 1.5 2+ Hospitalization time 15% Improvement Relative Risk Improvement in lung Ct 51% c19early.com/gaynitdinova.html Favors N-acetylcysteine Favors control
19 February 2021 - Late treatment study
N-acetylcysteine as a part of complex treatment of moderate COVID-associated pneumonia
Gaynitdinova et al., Pulmonologiya, doi:10.18093/0869-0189-2021-31-1-21-29 (Peer Reviewed)
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RCT 46 hospitalized patients with moderate COVID-19 pneumonia, 24 treated wth N-acetylcysteine, showing significantly shorter hospitalization with treatment. NAC 1,200 – 1,500mg/day intravenously.
hospitalization time, 15.4% lower, relative time 0.85, p < 0.001, treatment 24, control 22.
relative improvement in lung Ct, 50.7% better, RR 0.49, p < 0.001, treatment 24, control 22.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Gaynitdinova et al., 2/19/2021, Randomized Controlled Trial, Russia, Europe, peer-reviewed, 6 authors, average treatment delay 7.0 days.
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