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0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk Ventilation -37% c19rmd.com Fried et al. Remdesivir for COVID-19 LATE TREATMENT Favors remdesivir Favors control
Fried, 11,721 patient remdesivir late treatment study: 61% lower mortality [p=0.02] and 37% higher ventilation [p=0.25] https://c19p.org/frieds
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Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States
Fried et al., Clinical Infectious Disease, doi:10.1093/cid/ciaa1268
28 Aug 2020    Source   PDF   Share   Tweet
Database analysis of 11,721 hospitalized patients, 48 treated with remdesivir.
Data inconsistencies have been found in this study, for example 99.4% of patients treated with HCQ were treated in urban hospitals, compared to 65% of untreated patients (Supplemental Table 3), while patients are distributed in a more balanced manner between teaching or not-teaching hospitals, as well as in the most urbanized (Northeast) and less urbanized (Midwest) regions of the United States [academic.oup.com].
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 61.2% lower, RR 0.39, p = 0.02, treatment 4 of 48 (8.3%), control 2,510 of 11,673 (21.5%), NNT 7.6, remdesivir vs. non-remdesivir.
risk of mechanical ventilation, 36.8% higher, RR 1.37, p = 0.25, treatment 11 of 48 (22.9%), control 1,956 of 11,673 (16.8%), remdesivir vs. non-remdesivir.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups, substantial unadjusted confounding by indication likely.
Fried et al., 28 Aug 2020, retrospective, database analysis, USA, peer-reviewed, 11 authors.
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